Dr Tim Sargeant is head of Lysosomal Health in Ageing in the Hopwood Centre for Neurobiology (formally the Lysosomal Diseases Research Unit) at SAHMRI in 2015. His current research focuses on the role of lysosomal recycling in common age-related disease such as Alzheimer’s disease. The lysosomal system is important for slowing cell ageing, as it removes damaged and unwanted material from the cell. This process is critically important for healthy brain function. Work from Lysosomal Health in Ageing has shown that this system is damaged in Alzheimer’s disease, and that changes in genes that are involved in the lysosomal system are associated with Alzheimer’s disease. Tim's current research focuses on development of methods for measurement of lysosomal system activity (through a process called autophagy) in humans, as well as developing interventions that improve the lysosomal system with the goal of delaying Alzheimer’s disease.